Item

Items generally refer to the medicines that are used to help the Pokémon gain their energy back faster or cure them entirely. As well as they may be avaible to be bought, they can also be prepared by specific recipes. is stated to know a bit of recipes due to her experience at Day Care Service. There is also Redemy Book owned by. According to what is stated, Redemy Book was written by Eshmun after the World War. The book contains Eshmun's entire knowledge of the medicines.

Hyper Potion
Hyper Potion is first mentioned in when Redwald is meant to find one in Cerulean Trial Site, which he in the end finds in a cave in the area. In, Misty rewarded with that Hyper Potion in the last round of their Gym battle.

Revive
Revive is mentioned for the first time in. Professor Oak requested all of his students to find a proper item and 's task was to find a revive, which he eventually did. Revive helps a fainted Pokémon to get sober and gain a little energy.

Antidote
Greta's task was to find an antidote in when it is first time mentioned. Antidote heals the poison in the body quickly. When was poisoned in, Greta and  prepared an antidote by using natural herbs, such as peppermint, evening primrose oil, feverfew, ginger and witch hazel, that can be found in Viridian Forest.

Evolutionary Stones
Evolutionary stones are used to evolve certain Pokémon.